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The Smc5, Smc6 and MAGE mutants described here are also sensitive to IR (40 Gy), HU (four mM to eight mM), camptothecin (.025 mM) and MMS (.05.015%), constant with an evolutionarily conserved function in resistance to genotoxic brokers. Components of the Smc5/6 sophisticated might be responsible for present Drosophila mutagen delicate (mus) mutants (e.g. [fifty eight]) or may not but be represente
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